Pharmacokinetic-pharmacodynamic modeling and simulation by Peter L Bonate, SpringerLink

Pharmacokinetic-pharmacodynamic modeling and simulation Peter L Bonate, SpringerLink ebook
Publisher: Springer
Page: 394
Format: pdf
ISBN: 0387271996, 9780387271996

Population Pharmacokinetic/Pharmacodynamic Modeling of Clopidogrel in Korean Healthy Volunteers and Stroke Patients. By providing this infrastructure Devidas believes the partners can maximise the usefulness of pharmacokinetic/pharmacodynamic modeling and simulation (M&S) and increase its value in the drug development process. Mefloquine Pharmacokinetic-Pharmacodynamic Models: Implications for Dosing and Resistance. Pharmacokinetic-pharmacodynamic modeling and simulation, Peter L. Results (preliminary): The Aarons L, Kyle DE, White NJ. Mechanistic within-host models relating blood anti-malarial drug concentrations with the parasite-time profile help in assessing dosing schedules and partner drugs for new anti-malarial treatments. This can be a second version to the original published by Springer in 2006. A comprehensive simulation study to assess the utility of a stage-specific pharmacokinetic-pharmacodynamic (PK-PD) model for predicting within-host parasite response was performed. Designing these studies is The derived optimal designs were then evaluated via a simulation-estimation procedure. This finding provides motivation for conducting more pharmacokinetic-pharmacodynamic (PK-PD) studies of artesunate to monitor its effectiveness and re-assess current dosing regimens. Joomi Lee, MS; Yangha Hwang Financial disclosure: This research was supported by the Korea National Enterprise for Clinical Trials, a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, the Republic of South Korea (A070001), and by the Pfizer Modeling & Simulation Education Center in Korea (PMECK).